摘要
目的分析胃黏膜上皮内瘤变癌变患者的临床特征,以期提高胃早癌的检出率。方法收集2011年7月-2013年6月苏州大学附属第一医院消化内镜中心检出的胃黏膜上皮内瘤变患者294例,其中低级别上皮内瘤变(LGIN)患者170例,高级别上皮内瘤变(HGIN)患者124例,发现癌变患者72例,分析患者的临床特征,比较癌变患者一般情况、病灶形态、幽门螺杆菌(H.pylori)感染、胃黏膜萎缩肠化等方面与非癌变上皮内瘤变患者的差异。结果癌变组患者平均年龄、贲门胃底发生率、H.pylori总感染率、萎缩发生率、肠化率与非癌变组相比均明显增高(P<0.05);癌变与非癌变患者在性别、临床表现、形态上无明显差异(P>0.05)。结论患者年龄较大、病变位于贲门胃底且伴有H.pylori感染、胃黏膜萎缩肠化的HGIN应高度怀疑其癌变,加强内镜随访。
Objective To analyze the clinical characteristics of gastric mucosa intraepithelial neoplasia with cancera- tion in order to improve the detection rate of early-stage cancer. Methods Total 294 patients in the First Hospital Affil- iated to Suzhou University from Jul. 2011 to Jun. 2013 were retrospectively analyzed. All patients were diagnosed as gastric mucosa intraepithelial neoplasia confirmed by biopsy. There were 72 cases of canceration patients among 170 ca- ses of low grade intraepithelial neoplasia （LGIN） and 124 cases of high grade intraepithelial neoplasia （HGIN）. Clini- cal characteristics including common status, lesion morphology, H. pylori infection, atrophic gastritis, intestinal metapla- sia and so on were analyzed. Results The average age, the location in cardia-fundus of stomach, H. pylori infection, atrophic gastritis and intestinal metaplasia of canceration group were much higher than that of non-canceration group （P 〈 0.05）. There was no difference in gender, clinical symptoms, and lesion morphology between canceration group and non-eanceration group. Conclusion The lesion located in cardia-fundus of stomach in the elder patients, accompanied with H. pylori infection, atrophic gastritis, intestinal metaplasia should be highly suspicious of canceration which needs endoscopic follow up to improve its early-detection rate of canceration.
出处
《胃肠病学和肝病学杂志》
CAS
2015年第5期569-571,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
胃黏膜上皮内瘤变
低级别上皮内瘤变
高级别上皮内瘤变
早癌
Gastric mucosa intraepithelial neoplasia
Low grade intraepithelial neoplasia
High grade intraepithelialneoplasia
Early-stage cancer
