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2型糖尿病易感基因研究进展 被引量：8

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摘要 2型糖尿病（T2DM）是由于胰岛素抵抗和B细胞分泌缺陷导致高血糖的一种复杂多基因疾病，其发病机制至今尚未完全阐明。遗传因素在T2DM的发生发展中起着重要作用，同时其发病还受到环境因素的影响，因而具有较强的异质性。在过去的几年中，复杂疾病的遗传学研究及分子生物学发展迅速，限制性片断长度多态性及聚合酶链反应以及特异序列寡核苷酸探针等技术陆续应用到T2DM人群易感基因的研究。近几年全基因组扫描的开展，使T2DM遗传学研究达到前所未有的高度。本文对这些新的研究结果进行归纳综述。
作者 丁晓慧 杨泽
机构地区 卫生部北京医院
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2010年第4期311-313,共3页 Chinese Journal of Diabetes
关键词 糖尿病 2型 胰岛素抵抗 全基因组相关研究 全基因组扫描 单核苷酸多态性
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献16

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二级参考文献14

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  • 10Fenghua Yi,Patricia L.Brubaker,Tianru Jin.TCF-4 Mediates Cell Type-specific Regulation of Proglucagon Gene Expression by β-Catenin and Glycogen Synthase Kinase-3β[J].The Journal of Biological Chemistry Vol.280.No.2,Issue of January 14,pp.1457-1464. 被引量：1

同被引文献100

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二级引证文献28

中国糖尿病杂志
2010年 第4期

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