摘要
目的比较苯磺酸左旋氨氯地平和硝苯地平治疗高血压的降压作用和不良反应。方法选取门诊患者105例,随机分为两组,治疗组65例,对照组40例,分别给予苯磺酸左旋氨氛地平片2.5～5.0mg/d,和硝苯地平控释片30～45mg/d,共治疗4周,观察降压效果和不良反应。结果治疗前后两组血压均有明显下降(P(0.05),两组间差异无统计学意义(P>0.05)。治疗组与对照组的总有效率分别为89.23%和87.50%,差异无统计学意义(P>0.05)。治疗2周后,白天和夜间的收缩压血压变异(BVP)幅值治疗组均比对照组低(P<0.05)。4周后白天和夜间的收缩压BVP幅值两组均进一步下降,治疗组仍比对照组低(P<0.05)。对照组出现不良反应4例(10.00%),治疗组仅2例(3.08%),治疗组不良反应率明显较对照组低(P<0.05)。结论苯磺酸左旋氨氯地平和硝苯地平控释片虽有相似的降压疗效,但前者还有减轻血压变异和不良反应的疗效,值得临床推广。
Objective To investigate the action and adverse drug reaction of levoamlodipine tables and nifedipine in hypertensive disease.Methods 105 patients with hypertensive disease were randomizedly divided into two groups：treatment group（65 cases） and control group（40 cases）.The treatment group received levoamlodipine besylate tablet 2.5-5.0 mg daily and control group,nifedipine tablets 30-45 mg daily for 4 weeks,respectively.The antihypertensive efficacy and adverse drug reaction were observed respectively.Results The two groups’ blood pressures dropped obviously（P〈0.05） after taking drugs.But the total effective rates in treatment group and control group were 89.23% and 87.50% respectively,there was no distinct difference in two groups（P〉0.05）.After two weeks treatment,the width of blood variation pressure（BVP） of systolic blood pressure in daytime and nighttime dropped obviously than that in control group（P〈0.05）.After four weeks treatment,the width of BVP dropped further,the treatment group was obviously lower than control group（P〈0.05）.In control group,there were 4 cases（10.00%） presenting some adverse drug reaction and in treatment group,there was only one cases（3.08%）.There was distinct statistical difference（P〈0.05） between the two groups.Conclusion The two drugs had obvious effects on hypertension disease,but the rate of adverse reaction of the levoamlodipine mleate tables was obviously lower than that of the nifedipine.It was worthly recommended drug for hypertension disease.
出处
《中华全科医学》
2010年第5期578-579,共2页
Chinese Journal of General Practice
