摘要
目的探讨急性脑梗死患者外周血中血小板膜糖蛋白Ibα(GPIbα)和血管性假性血友病因子(vWF)表达水平的变化规律及脑梗死类型和高血压病、糖尿病对其影响。方法 95例脑梗死患者和20例健康体检者分别分为1,病例组;2,对照组。并探讨高血压病、糖尿病及脑梗既往史对急性脑梗死患者外周血GPIbα和vWF表达水平是否有影响。用流式细胞仪检测外周血GPIbα表达水平,用免疫比浊法检测vWF表达水平。结果急性脑梗死患者外周血GPIbα的阳性表达率明显低于对照组(P<0.05),vWF的阳性表达率显著高于对照组(P<0.05);同时合并高血压病和糖尿病的急性脑梗死患者外周血GPIbα的阳性表达率明显高于单纯急性脑梗死组(P<0.05)。既往有脑梗史患者外周血GPIbα和vWF的阳性表达率与既往无脑梗死组相比没有统计学意义(P>0.05);梗死面积和是否合并高血压病对于急性脑梗患者外周血GPIbα和vWF的阳性表达率影响没有统计学意义(P>0.05)。结论外周血GPIbα和vWF的表达水平在一定程度上可用于辅助判断急性脑梗死病例;糖尿病和高血压病对急性脑梗死患者外周血GPIbα的表达水平有显著影响。
Objective To investigate the changes and its significance of the level of plasma GPIb α and vWF in patients with different types and complications of acute cerebral infarction and the control group of healthy people. Methods 95 patients with acute cerebral infarction and 20 healthy volunteers were studied. Whether diabetes, hypertension and the past history of cerebral infarction influenced the levels of plasma GPIb α and vWF in patients with acute cerebral infarction were determined. Plasma GPIbα and vWF were measured by flow cytometry and immunoturbidimetry. Results The level of plasma GPIbα in patients with acute cerebral infarction was significantly lower than that in the control group（P〈0.05）;and higher in vWF（P〈0.05）in patients of acute cerebral infarction. But there were no significant differences between the patients with and without histories of cerebral infarction（P〉0.05）. The complications of hypertension and diabetes had significant influences to level of plasma GPIb α in patients with acute cerebral infarction.The area of infarction and hypertension had no significant influence to the level of plasma GPIbα and vWF. Conclusion The levels of plasma GPIb α and vWF may help to identify the patients with acute cerebral infarction. The complications of hypertension and diabetes have significant influence to level of plasma GPIb α in patients with acute cerebral infarction.
出处
《云南医药》
CAS
2010年第2期142-146,共5页
Medicine and Pharmacy of Yunnan
