摘要
目的:探讨心型脂肪酸结合蛋白(H-FABP)在早期急性脑梗死患者血清中的表达及临床意义。方法:采用酶联免疫吸附法检测95例急性脑梗死患者血清H-FABP、神经元特异性烯醇酶(NSE)和S100蛋白B(S100B),观察三者在急性脑梗死患者中的浓度并比较三者的敏感性。结果:急性脑梗死发病早期(24h内),血清中均可检测到H-FABP、NSE、S100B,且均显著高于对照组(P<0·0005);H-FABP敏感性显著高于NSE和S100B(P<0·005);神经功能缺损严重患者的早期血清H-FABP浓度较高(P<0·05)。结论:急性脑梗死患者早期血清H-FABP、NSE和S100B均有表达,但H-FABP最敏感,可作为早期诊断急性脑梗死的生物学指标。
Objectives： To discuss the expression of heart fatty acid binding protein （H-FABP） in patients with acute cerebral infarction and its clinical significance. Methods： Serum H-FABP, neuron specific enolase （NSE） and S100 protein B （S100B） were detected by using enzyme linked immunosorbent assay （ELISA） in ninety-five patients with acute cerebral infarction, their sensitivity was compared. Results： The serum H-FABP, NSE and S100B were detected in early acute cerebral infarction （within 24 hours）, and they were all significantly higher than those in control group （P 〈0. 000 5）. The sensitivity of H-FABP was significantly higher than that of NSE and S100B （P 〈0.005）. The early levels of serum H-FABP in patients with severe neurological defect were higher （P 〈0.05）. Conclusions： The early serum H-FABP, NSE and S100B all expressed in patients with acute cerebral infarction, however, H-FABP was the most sensitive one. It may be used as a biological marker in early diagnosis of acute cerebral infarction.
出处
《国际脑血管病杂志》
2006年第9期648-650,共3页
International Journal of Cerebrovascular Diseases
基金
苏州市青年科技基金(项目编号:SWQ21)
关键词
心型脂肪酸结合蛋白
急性脑梗死
生物学指标
heart fatty acid binding protein
acute cerebral infarction
biological marker
