摘要
目的:检测第10号染色体缺失的磷酸酶和张力蛋白同源物基因PTEN及表皮生长因子受体EGFR在胃癌组织中的表达,探讨两者与胃癌肿瘤行为的关系及意义。方法:采用免疫组织化学染色法(S-P法)检测105例胃癌组织及癌旁正常胃组织中EGFR和PTEN蛋白的表达水平,并将检测结果与临床病理参数进行综合分析。结果:胃癌组织PTEN的表达56.19%明显低于正常组织中的表达的表达92.3%,而胃癌组织EGFR的表达46.67%明显高于正常组织7.62%,(P<0.01)。二者的表达与性别和年龄无相关性(P>0.05),与胃癌的分化程度、浸润深度、淋巴结转移及临床分期有相关性(P<0.05)。结论:PTEN在胃癌组织中呈低表达,EGFR在胃癌组织中存在高表达,与胃癌的发生、发展有一定关系,并与胃癌的分化程度、浸润深度、淋巴结转移及临床分期密切相关,二者呈负相关。
Objective：To investigate expression of PTEN and EGFR in gastric carcinoma and to explore its relationship with the genesis and development of gastric carcinoma and its relationship with clinicopathological parameters. Methods：Immunohistochemistry（S-P） was used to detect the expression of PTEN and EGFR protein in 105 case of gastric carcinoma tissues and their adjacent normal gastric tissues. Results：In the normal gastric tissue,the positive rate of PTEN protein（92.3%） were higher than those in gastric cancer tissue（56.19%） . The over expression of EGFR in gastric carcinoma was higher than that in normal gastric tissues（7.62%） （ P 0. 01） . Their expression were unrelated with gender and age of gastric carcinoma（P0.05） ,but closely correlated with levels of histological differentiation and clinical pathology stages. Conclusions：The PTEN protein expression flaw and over expression of EGFR which may play certain role in the genesis and development of gastric carcinoma and closely related the degree of differentiation,depth of invasion,lymph node metastasis and clinical stages. There was negative trend between PTEN expression and EGFR in gastric carcinoma.
出处
《现代生物医学进展》
CAS
2010年第2期316-319,共4页
Progress in Modern Biomedicine
