摘要
目的:探讨表皮生长因子受体(Epidermal group pactor,EGFR)和血管内皮生长因子(Vascalia endothelial grouth factor,VEGF)在乳腺癌中表达状况及临床意义。方法:收集乳腺癌标本86例、腺瘤46例。利用免疫组织化学技术检测EGFR和VEGF阳性表达率,并分析它们之间的相关性。结果:EGFR和VEGF在乳腺腺瘤中阳性率为13.04%(6/46)和34.78%(16/46);它们在乳腺癌中阳性率前者为56.98%(49/86),后者为54.65%(47/86),两者差异无显著性(P>0.05)。它们在乳腺癌中的阳性率明显高于腺瘤中的阳性率(P<0.05);在浸润型癌组(含小叶癌或导管浸润癌)的阳性率明显高于非浸润型癌组(含小叶及导管内癌)。在有淋巴结转移组阳性率明显高于无转移组(P<0.05)。结论:EGFR和VEGF高表达与乳腺癌发生及转移有相关性,而且两者呈正相关。检测乳腺癌EGFR和VEGF对靶向化学治疗有指导作用。
Objective： To detect the expression of epidermal growth factor receptor （EGFR） and vascular endothelial growth factor （VEGF） and to determine its significance in breast cancer. Methods： EGFR and VEGF expression was detected by immunohistochemistry in 86 breast cancer tissues and 46 adenoma tissues, and their relationship was analyzed. Results： The positive rates of EGFR and VEGF expression were 13.04%（6/46） and 34.78%（16/46）, respectively, in breast adenoma tissues and 56.98% （49/86） and 54.65%（47/86）, respectively, in breast cancer tissues. No significant difference was found between EGFR expression and VEGF expression （P〉0.05）. The positive rates of EGFR and VEGF in breast cancer tissues were higher than those in adenoma tissues（P〈0.05）. The positive rates in the infiltrating cancer group （infiltrating lobular carcinoma and ductal carcinoma） were higher than those in the non-infiltrating group （lobular carcinoma in situ and intraductal carcinoma）（P〈0.05）. The positive rates of EGFR and VEGF in the group with lymph node metastasis were higher than those in the group without lymph node metastasis （P〈0.05）. Conclusion： The expression of EGFR and VEGF is positively correlated to breast cancer occurrence and lymph node metastasis. The detection of EGFR and VEGF is helpful for targeted chemotherapy.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2007年第23期1324-1326,共3页
Chinese Journal of Clinical Oncology
基金
河北省科技厅攻关项目基金资助(编号:03276117)
关键词
乳腺癌
腺瘤
表皮生长因子受体
血管内皮生长因子
免疫组织化学
Breast cancer Adenoma Epidermal growth factor receptor （EGFR）Vascular endothelial growth factor （VEGF） Immunohistochemistry
