摘要
目的探讨PTEN基因在非小细胞肺癌中的表达及临床意义。方法应用免疫组织化学法检测65例非小细胞肺癌组织及18例非肺癌组织中PTEN的表达。结果①PTEN在非小细胞肺癌组织中的阳性率为41.54%,显著低于非肺癌组织的阳性率88.89%(P<0.05);②PTEN的表达与肺癌患者的细胞分化程度、pTNM分期、淋巴结转移、生存期密切相关(P<0.05)。细胞分化程度越低,TNM分期越晚,PTEN阳性率越低;有淋巴结转移组PTEN蛋白阳性率(28.89%)显著低于无淋巴结转移组(70.00%);生存期≤5年组(24.39%)PTEN的阳性表达率低于生存期>5年组(70.83%)。PTEN与病理类型无关(P>0.05)。结论PTEN与非小细胞肺癌的临床特征和生物学行为密切相关,PTEN的检测将有助于评估肺癌患者的恶性程度和预后。
Objective To study the PTEN gene expression and its clinical significance in NSCLC.Methods The expression of PTEN was detected in 65 NSCLC and 18 non-cancerous lung tissues by the immunohistochemical staining. Results ①PTEN expression in NSCLC was 41.54% significantly lower than non-cancerous lung tissues 88.89% （P 〈 0.05）. ②The expression of PTEN gene significantly correlated with grade of cell differentiation , pTNM stages, lymph node metastasis and the survival date （ P 〈 0.05）. The lower cytodifferentiation was, the later pTNM stages was, the lower PTEN positive would be. The positive rate of PTEN was lower in lymph node metastasis （28.89%） than that in non-lymph node metastasis （70.00%）. The positive rate of PTEN was lower in life span less than five years （24.39 % ） than in life span more than five years （70.83 % ）. PTEN expression had no relevance with the pathological type. Conclusion PTEN expression significantly correlates with the clinico-pathologic, characteristics and biologic behavior in NSCLC. Detection of PTEN may be valuable for diagnosing lung cancer and evaluating malignant extent and prognosis.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2006年第5期394-396,共3页
Journal of Harbin Medical University
