摘要
目的通过检测不稳定性心绞痛(UAP)患者血清中1型辅助性T细胞(Th1)和2型辅助性T细胞(Th2)细胞因子的变化,探讨其在UAP发病过程中的作用及对近期预后的判断价值。方法选取UAP患者42例(UAP组),稳定性心绞痛(SAP)患者34例(SAP组),同时选取健康体检者22例(对照组)。测定各组血清中的γ-干扰素(IFN-γ)、白细胞介素(IL)-2、IL-4和IL-10水平,并观察UAP患者3个月内不良心脏事件发生率。Th1细胞因子包括IFN-γ、IL-2,Th2细胞因子包括IL-4、IL-10。结果 UAP组血清中IFN-γ、IL-2水平明显高于对照组和SAP组,而IL-4、IL-10水平明显低于对照组和SAP组(P<0.05)。UAP患者中,有心脏事件患者血清IFN-γ、IL-2水平明显高于无心脏事件患者,IL-10、IL-4水平明显低于无心脏事件患者(P<0.05)。结论外周血中Th1和Th2细胞因子水平变化可能与冠状动脉病变不稳定性斑块的存在有关,可反应冠心病患者临床病情,对判断UAP患者近期预后有较好的预测价值。
Objective To study the peripheral blood Thl and Th2 cytokines in patients with unsta- ble angina peetoris（UAP） in order to value the role of Th1 and Th2 subsets in the development of UAP. Methods Forty-two patients with UAP, 34 patients with SAP and 22 healthy volunteers were enrolled in the study. Serum levels of the Thl and Th2 cytokines, including IFN-γ, IL-2, IL-4 and IL-10,were measured. The incidents of major cardiac events in three months were observed. All patients were evaluated with coronary angiography and coronary artery injury. Results The levels of IFN-γ and IL-2 were elevated in patients with UAP compared with those in patients with SAP and controls. The levels of IL-4 and IL-10 were decreased in patients with UAP compared with those in patients with SAP and controls. Among patients with UAP,the levels of IFN-γ and IL-2 were significantly higher in cardiac event group than in no-cardiac events group （P 〈 0.05）. The levels of IL-10 and IL-4 were significantly lower in cardiac event group than in no-cardiac events group （P 〈 0.05）. Conclusion Serum levels of Thl and Th2 cytokines may have diagnostic value for forecasting the incidents of UAP, and can be a useful marker to value the stabilization of the disease. They can predict the prognosis of patients with unstable angina pectoris.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2010年第4期313-315,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
