摘要
目的探讨急性冠脉综合征患炎症因子水平的变化情况。方法选择70例急性冠脉综合征患者,用ELISA或放免分析法对其血清中C-反应蛋白(CRP)、ET-1、OX-LDL免疫复合物及肿瘤坏死因子-α(TNF-α)、可溶性血管细胞间粘附分子-1(sVCAM-1)、白细胞介素-1(IL-1β)水平进行了测定。并与30例正常对照组比较。结果急性冠脉综合征患者血清CRP、OX-LDL-IC、IL-1β、TNF-α及sVCAM-1浓度明显升高于正常对照组(P<0.01)。结论急性冠脉综合征患者体内血清有多种细胞因子水平增高,提示炎症与急性冠脉综合征的发病有关。
Objective To investigate the inflammatory factors activation level in patients with acute coronary syndrome.Methods CRP,ET-1,OX-LDL,TNF-α,sVCAM-1 and IL-1β were detected by ELISA or radioimmunoassay in 70 patients with acute coronary syndrome and 30 controls.Results Serum concentrations of CRP,OX-LDL-IC,IL-1β,TNF-α and sVCAM-1 in patients with acute coronary syndrome were significantly higher than that in controls(P<0.01).Conclusion The raise of inflammatory factors in the study suggests the relationship between inflammation and acute coronary syndrome.
出处
《吉林医药学院学报》
2006年第3期138-139,142,共3页
Journal of Jilin Medical University
基金
2004年百色市科学研究与技术开发计划项目(百科技字[2004]8号).
关键词
炎症因子
急性冠脉综合征
inflammatory factors
acute coronary syndrome
