摘要
目的:探讨他汀类药物在防治慢性心力衰竭(CHF)患者心肌纤维化、逆转心室重塑的作用。方法:入选CHF患者69例,随机分为治疗组(35例)和对照组(34例)。两组均给予ACEI、利尿剂、地高辛和β-阻滞剂治疗。治疗组加用普伐他汀20mg口服,每晚1次,共服12周。治疗前及治疗后12周分别检测Ⅲ型前胶原氨基末端肽(PⅢNP)并评价左室功能指标。结果:治疗12周后治疗组PⅢNP、LVEF、LVMI、LVEDVI、LVESVI均较治疗前有明显改善(P<0.01);对照组PⅢNP、LVEDVI、LVESVI较治疗前有所改善(P<0.05),LVEF、LVMI改善不明显(P>0.05)。治疗12周后普伐汀治疗组PⅢNP、LVEF、LVMI、LVEDVI、LVESVI均较对照组有明显改善(P<0.05)。结论:短期小剂量普伐他汀治疗有改善CHF患者心肌纤维化的作用,改善患者的左心室重塑。
Objective： The aim of this study was to investigate the effects of statins on myocardium fibrosis and ventricular remodeling： Methods：69 patients were randomly devidied into two groups：the treatment group （n=35） and the control group （n=34）. Both groups were received the similar dosage ACEI, diuresis, digoxin, andβ-blocker. The treatment group received additional pravastatin 20mg/d. PⅢNP and cardic function parameter were measured before and 12 weeks after intervation respectively. Results：There were no significant difference in age, PⅢNP, LVEF, LVMI. LVEDVI, LVESVI and NYHA class between the control and treatment group p〉0.05）.The data of two groups was equilibria and could be comparised; After 12 weeks treatment the level of PⅢNP, LVEF, LVMI,LVEDVI,LVESVI were significantly improved more than before treatment in the treatment group and there were statistics significant（all P〈0. 01）.;After 12 weeks treatment there Were statistics significant in the level of PⅢNP, LVEF, LVMI,LVEDV1,LVESVI between the treatment group and the control group（all P〈0.05）. Conclusion：Short-term low dose pravastatin treatment in CHF may reduce myocardium fibrosis;Short-term low dose pravastatin treatment in CHF may improve left ventricular remodeling.
出处
《中国医药导刊》
2010年第2期256-257,共2页
Chinese Journal of Medicinal Guide
关键词
心力衰竭
心肌纤维化
普伐他汀
Ⅲ型前胶原氨基末端肽
心室重塑
heart failure
myocardium fibrosis
pravastatin
procollagen type Ⅲ amino-terminal peptide
ventricular remodeling
