摘要
目的探讨环氧化酶-2(COX-2)在口腔鳞状细胞癌中的表达及其与淋巴管生成的相关性。方法应用免疫组化SP法检测口腔鳞状细胞癌中COX-2及D2-40的表达情况,并计数淋巴管密度(lymphatic vessel density,LVD)。结果和正常组织比较,口腔癌中COX-2的表达明显增高,有淋巴结转移的口腔鳞状细胞癌患者COX-2的阳性率显著高于无淋巴结转移组(χ2=6.435,P<0.05),LVD计数显著高于无转移组(t=2.446,P<0.05),口腔鳞状细胞癌中COX-2与LVD之间具有相关性(r=0.552,P<0.05)。结论COX-2与口腔鳞状细胞癌的淋巴管生成有关,在口腔鳞状细胞癌的淋巴结转移中可能起着重要作用。
Objective To investigate the correlation between expression of COX-2 and lymphangiogenesis in oral squamous cell carcinoma.Methods The expression of COX-2 and D2-40 in oral squamous cell carcinoma was evaluated by using immunohistochemistry,and the number of D2-40 positive lymphatic vessels were regarded as lymphatic vessel density（LVD）.Results The expression of COX-2 in oral squamous cell carcinoma was higher than that in normal tissue,and the expression of COX-2 and LVD in oral squamous cell carcinoma with lymph node metastasis was significantly higher than that without lymph node metastasis respectively,the difference was statistically significant（P〈0.05）.COX-2 expression was correlated with LVD in oral squamous cell carcinoma（r=0.552,P〈0.05）.Conclusion COX-2 is a significant factor for lymphangiogenesis,which may be involved in the lymph node metastasis in oral squamous cell carcinoma.
出处
《现代口腔医学杂志》
CAS
CSCD
2010年第2期131-134,共4页
Journal of Modern Stomatology
