摘要
再生障碍性贫血是血液系统常见病、多发病,由多种原因造成骨髓造血功能衰竭,以全血细胞减少为特征的一种临床综合征。中医学认为"再生障碍性贫血"的发病机制为气血两虚。当归为益气、补血中药有造血刺激作用。随着细胞培养技术、药物学、分子生物学等研究技术的发展,不少学者对当归造血刺激作用机制进行深入研究并取得许多成果,结合近年文献,主要从促进造血干细胞增殖、抑制其凋亡、改善造血微环境、调节免疫及相关信号通路等方面阐述当归造血刺激作用机制。
Aplastic anemia,an usual hematologic disease,is characterized by peripheral blood cytopenia and bone marrow failure.The pathogenesis of aplastic anemia is considered to be both deficient of QI and Blood in traditional Chinese medicine.Angelica has been used for raising the “Qi” and nourishing the “Blood” of the individual and have been shown favorable effects on aplastic anemia by Stimulating the proliferation of bone marrow cells,anti-apoptosis,modulating immune activities and improving the hematopoietic microenvironment.Now we review the mechanism of angelica on hematopoiesis.
出处
《医学综述》
2010年第7期1089-1091,共3页
Medical Recapitulate
