摘要
目的探讨P53与β-catenin在胃息肉和胃癌中的表达及相互关系。方法采用免疫组化法检测正常胃黏膜组、不同病理类型的胃息肉组和胃癌组中P53蛋白与β-catenin蛋白的表达情况。结果(1)P53蛋白的阳性率:胃癌组明显高于正常胃黏膜组和不同类型的胃息肉组(P<0.05);正常胃黏膜组和不同类型的胃息肉组间差异,均不具有统计学意义(P>0.05)。β-catenin蛋白的阳性率:胃癌组和不同类型的胃息肉组明显高于正常胃黏膜组(P<0.05);胃癌组和不同类型的胃息肉组间差异,均不具有统计学意义(P>0.05)。(2)β-catenin蛋白的强阳性率:胃癌组明显高于不同类型的胃息肉组,差异均具有统计学意义(P<0.05)。结论在胃息肉阶段抑癌基因P53保持相对正常的结构和功能,癌基因β-catenin表达增强,增强的程度明显低于胃癌阶段。
Objective To discuss the correlation of P53 and β-catenin expression in gastric polyp and gastric carcinoma.Methods The expression of P53 protein andβ-catenin protein were examined using immunohistochemical staining in normal gastric mucosa group（group A） and different pathologic types of gastric polyps group（group B） and gastric carcinoma group（group C）.Results The positive rates of P53 protein in group C were obviously higher than that in group A and group B（P〈0.05）.Between the group A and group B,there were no significant differences in the positive rates of P53 protein（P〉0.05）.The positive rates of β-catenin protein in group C and group B were obviously higher than that in group A（P〈0.05）.Between the group C and group B,there were no significant differences（P〉0.05）.The strong positive rates of β-catenin protein in group C were higher than that in group B（P〈0.05）.Conclusion Tumor suppressor gene P53 keeps relatively normal construction and function in gastric polyp,however,the expression of oncogene β-catenin in gastric carcinoma were higher than in gastric polyp.
出处
《黑龙江医学》
2010年第2期93-95,共3页
Heilongjiang Medical Journal
