摘要
目的观察前列腺素E1脂微球(Lipo PGE1)对肺心病并心力衰竭病人脑钠肽(BNP)的影响。方法将120例肺源心脏病病人随机分为治疗组和对照组,各60例。两组治疗期间均停用其他扩血管药物,给予控制诱因、持续低流量吸氧、强心、利尿等常规抗心力衰竭治疗,积极抗感染、纠正电解质及酸碱失衡等,治疗组在一般治疗基础上给予Lipo PGE110μg/d静脉推注,疗程14 d。比较两组治疗前后血BNP以及心脏指数(CI)。结果两组病人治疗后BNP较治疗前均显著降低(t=2.02、7.91,P<0.05、0.01),治疗组BNP较对照组显著降低(t=4.91,P<0.05)。治疗后两组病人CI较治疗前均显著增加(t=2.00、4.65,P<0.05、0.01),且治疗组CI显著大于对照组(t=3.59,P<0.05)。结论静脉推注Lipo PGE1治疗肺心病并心力衰竭疗效显著,在明显降低BNP的同时可提高CI。
Objective To observe the effect of Lipo PGE1 on plasma levels of brain natriuretic peptide （BNP） in patients with pneumocardial disease （PD） complicated heart fallure. Methods This study comprised 120 patients with PD, who were equally randomized to treatment group and control group. During the treatment, other vasodilating agents were discontinued in both groups. They were given control of inducement, inhalation of low-flow oxygen, administration of diuretics and antibiotics. Those in the treatment group, intravenous Lipo PGEI 10μg/d was added for 14 days. BNP and cardiac index （CI） before and after treatment were compared. Results The plasma levels of BNP decreased significantly in both groups after the traetment （t= 2.02, P〈0.05;t= 7.91, P〈0.01）. Before treatment, the levels of BNP in the treatment group were significantly lower than that in control group （t=4.91,P〈0.05）. Clinbothgroupsincreased（t=2.00,P〈0.05;t=4.65,P〈0.01） after treatment and even higher in the treatment group （t=3.59,P〈0.05）. Conclusion Intravenous injection of Lipo PGE1 is effective for PD complica- ted heart failure, with significantly decreasing the plasma levels of brain natriuretic peptide and increasing the CI.
出处
《青岛大学医学院学报》
CAS
2010年第1期58-59,62,共3页
Acta Academiae Medicinae Qingdao Universitatis
基金
山东省卫生厅课题(鲁健办发[2005]9号)
关键词
前列地尔
肺心病
利钠肽
脑
心脏指数
alprostadil
pulmonary heart disease
natrruretie peptide, brain
cardiac index
