摘要
目的研究脑钠肽(BNP)对老年肺心病(PHD)患者早期诊断及预后评价的临床意义。方法根据心脏超声检查测定肺动脉平均压力(MPAP),将120例老年慢性阻塞性肺部疾患(COPD)患者分为MPAP正常组、MPAP升高组、PHD稳定期组、PHD加重期组。测定各组血浆BNP、血气分析及心功能指标,比较其治疗后随访12个月的再入院率。结果BNP与MPAP存在直线相关关系(r=0.901,P<0.01),Cox回归分析显示BNP为预后因素(P<0.01)。结论BNP对老年PHD患者具有早期诊断及预后评价的临床价值。
Objective To study the clinical significance of brain natriuretic peptide （BNP） on early diagnosis and prognosis of corpulmonale in elderly patients. Methods 120 cases geriatric patients with chronic obstructive pulmonary disease（COPD） were divided into four groups, namely normal MPAP group , high MPAP group, stable PHD group , aggravated PHD group according to mean pulmonary artery pressure level after heart ultrasonograph examination. Blood plasma BNP levels , blood gas analysis parameters and heart function parameters of the four groups were measured, and their read-mission rates were compared after following up for 12 months. Results There was linear regression relationship between BNP and MPAP（r=0.901 ,P〈0.01）. Cox regression analysis is showed that BNP was the prognosis factor （P〈0.01）. Conclusions BNP has the clinical value on early diagnosis and prognosis evaluation of eldly PHD patients.
出处
《山东医药》
CAS
北大核心
2008年第25期20-21,共2页
Shandong Medical Journal
基金
山东省保健医学科研课题项目(200509)
关键词
脑钠肽
肺源性心脏病
老年
平均肺动脉压
brain natriuretic peptide
cor pulmonale, the elderly
mean pulmonary arterial pressure
