摘要
为了解血清ＡＣＡ水平与冠心病相关性，分别用ＥＬＩＳＡ和免疫比浊法对１４８名健康中老年人的ＡＣＡ－ＩｇＧ、ＩｇＭ、ＩｇＡ和ＴＣ、ＴＧ、ＨＤＬ含量进行了检测。同时测定了３４例住院冠心病人的ＡＣＡ水平。结果表明：在正常组，３类ＡＣＡ均随年龄递增（Ｐ＜０．０１和Ｐ＜０．０５），且男性高于女性（Ｐ＜０．０１和Ｐ＜０．０５），其中ＡＣＡ－ＩｇＧ的消长与血清ＴＧ呈正相关（Ｐ＜０．０５）；冠心病组的ＡＣＡ－ＩｇＧ阳性检出率明显高于正常组（Ｐ＜０．０１）。结果提示血清ＡＣＡ可能通过影响脂代谢参与了冠心病的发生。
To research the relation between serum ACA and coronary heart disease,serum ACA IgG,IgM,IgA and TC,TG,HDL were measured in 148 health middle age and senile population with ELISA and immune turbidity assay.The serum ACA in 34 patients with coronary heart disease was also detected.The result showed that there had a increased ACA level in health population as age growing(P<0 01 and P<0 05).The ACA levels in male was higher than in female(P<0 01 and P<0 05).It was also found that ACA IgG had a positive association with TG(P<0 05).The positive rate of ACA IgG in CHD group was markely higher than in normal control group(P<0 01).It is suggested that high level serum ACA IgG autoantibody maybe have a latent pathogenic effect in CHD forming by influencing lipometabolism.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
1998年第6期459-461,共3页
Chinese Journal of Immunology
关键词
抗心磷脂抗体
冠心病
甘油三脂
Anticardiolipin antibody Coronary heart disease TG
