摘要
目的探讨急性冠状动脉综合征的发病与抗心磷脂抗体(ACA)的相关性。方法用ELISA法对138例健康人、136例稳定性心绞痛患者、244例急性冠状动脉综合征患者和138例陈旧性心肌梗死患者的ACA水平进行检测。结果ACA阳性率:健康组1.45%、稳定性心绞痛患者16.1%、不稳定性心绞痛患者42.9%、急性心肌梗死患者为83.3%、陈旧性心肌梗死患者为34.8%;48例ACA阳性的不稳定性心绞痛患者有18例分别于3～26个月发生急性心肌梗死,发生率为37.5%,ACA阴性的64例患者无急性心肌梗死发生;138例陈旧性心肌梗死患者中,ACA阳性的48例有14例在2年内再发心肌梗死,发生率为29.2%,90例ACA阴性者中仅有2例再发心肌梗死,发生率为2.2%;132例急性心肌梗死患者中,年龄在30～42岁的16例患者ACA全部为阳性。结论部分急性冠状动脉综合征患者的发病可能与ACA阳性有关,尤以急性心肌梗死相关性明显,对不稳定性心绞痛是否会发生急性心肌梗死以及陈旧性心肌梗死是否再发梗死,ACA可能有预测价值;另外,ACA可能参与了年龄偏轻急性心肌梗死患者的发病过程。
Objective To investigate the correlation between anticardiolipin antibody（ ACA） and acute coronary syndrome（ ACS）. Methods ELISA was used to examine ACA levels in 138 healthy people, 136 patients with stable angina pectoris,244 patients with acute coronary syndrome and 138 patients with old myocardial infarction. Results The positive rates of ACA were 1.45% in control group, 16.1% in stable angina pectoris ,42. 9% in unstable angina pectoris ,83. 3% in acute myocardial infarction,and 34.8% in old myocardial infarction. The acute myocardial infarction occurs in 18 cases of 48 patients of unstable angina pectoris with positive ACA within 3 to 26 months, with the incidence rate of 37.5%, but the acute myocardial infarction did not occur in 64 patients of unstable angina pectoris with negative ACA. Of 138 patients with old myocardial infarction,there were 14 cases of 48 ACA positive patients suffering acute myocardial infarction within 2 years,with the incidence rate of 29.2% ,and only two cases of 90 ACA negative patients suffered acute myocardial infarction,with the incidence rate of 2.2%. In 132 patients with acute myocardial infarction,there were 16 patients aged between 30～42 and all of their ACA was positive. Conclusion The incidence of acute coronary syndrome in part of the patients may be related to ACA positive, especially acute myocardial infarction. ACA can also predict whether unstable angina pectoris will result in acute my- ocardial infarction or old myocardial infraction occurrs again,and it probably participates in the incidence of acute myocardial infarction in younger patients.
出处
《中国医药》
2006年第9期524-526,共3页
China Medicine
