摘要
目的探讨替米沙坦对糖尿病大鼠心肌微血管新生的促进作用。方法将雄性SD大鼠40只随机分为正常组(C组)、糖尿病模型组(D组)、替米沙坦干预组(T组)。给药12周末结束实验。用Western blot法分别检测心肌中肝细胞生长因子(HGF)表达,电镜下观察心肌微血管改变。结果D、T组心肌中HGF水平高于C组,T组高于D组。电镜下T组心肌细胞表面积和心脏血管细胞基底膜厚度小于D组。结论替米沙坦能够改善糖尿病心肌微血管病变,可能与增加糖尿病大鼠心肌HGF表达有关。
Objective To explore the effects of telmisartan to diabetic myocardial microvascular in type 2 diabetic rats.Methods Forty male SD rats were randomly divided into the normal group（C group）,diabetes model group（D group）,telmisartan intervention group（T group）.The experiment ended until 12 weeks given telmisartan.The semiquantitative expressions of HGF protein of myocardium were determined by western blot method.The myocardial microvascular ultrastructural was observed under EM（ele-ctron-microscopy）.Results The levels of HGF of myocardium of D and T group were elevated statisically compared with C group and HGF of T group were ete vated statisically compared with D group.Surface area of cardiac myocytes and thickness of basement membrane on vascular cell of T group were less than D group.Conclution Telmisartan can improve ultrastructure of myocardial microvascular of diabetic rats and its protective effect may be related to increation of HGF.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第3期270-272,共3页
Chongqing medicine
关键词
糖尿病
心肌
肝细胞生长因子
微血管
替米沙坦
diabetes mellit us
myocardium
hepatocyte growth factor
microvascular
telmisartan
