摘要
IL—12家族由结构相似的IL—12和新近发现的IL-23、IL-27组成。这3个细胞因子通过激活初始T细胞或记忆性T细胞诱导出不同的细胞因子表型，在多发性硬化（MS）和实验性自身免疫性脑脊髓炎（EAE）中发挥重要的作用：以前的观点认为IL-12在MS和EAE的发病中起着至关重要的作用，然而，最新发现，IL-23可通过诱导分化Th17细胞产生IL-17，在MS和EAE发病中起着重要的作用。IL-27在EAE和MS的发病过程中发挥双向调节作用．即早期发挥致炎作用，后期发挥抗炎作用。
Cytokine IL-12 and the recently discovered cytokine IL-23 and IL-27, which have a similar structure to cytokine IL-12, combine to form the IL-12 family. These three cytokines activate naive T cells or memory T cells and then induce different cytokine phenotypes and play an important role in the pathogenesis of multiple sclerosis （MS） and experimental autoimmune encephalomyelitis （EAE）. It was previously believed that only cytokine IL-12 played an important role in multiple sclerosis and experimental autoimmuue encephalomyelitis. However, the latest discovery shows that it is cytokine IL-23, but not IL-12, to produce cytokine IL- 17 through inducing and differentiating Th17 and promote the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis. Meanwhile, cytokine IL-27 has a dual effect： it induces inflammation at the onset and suppresses inflammation in the advanced stages.
出处
《国际免疫学杂志》
CAS
北大核心
2010年第1期19-22,共4页
International Journal of Immunology
基金
广西自然科学基金资助项目（桂科回0991009）
