摘要
目的:探讨中药升降散对脓毒症患者Th17/Treg失衡及相关调节因子RORγt和foxp3的干预作用。方法:将55例脓毒症患者随机分为西医组(27例)和升降散组(28例),另设健康志愿者9例为对照组。西医组患者给予西医常规治疗,并加用安慰剂100ml/次,2次/d,口服或鼻饲;升降散组患者在西医常规治疗的基础上加用升降散100ml/次,2次/d,口服或鼻饲;对照组患者给予口服安慰剂100ml/次,2次/d;疗程均为3d。比较治疗前后3组患者中医证候积分、血白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)、Th17/Treg及其特异性转录因子RORγt、foxp3的水平。结果:西医组与升降散组比较,治疗后中医证候积分、WBC、Th17/Treg、RORγt和foxp3差异均有统计学意义(P<0.05或P<0.01),2组患者治疗后CRP和PCT的差异无统计学意义;2组与对照组比较,治疗前后各项指标差异均有显著统计学意义(P<0.01)。结论:升降散可改善脓毒症患者中医证候积分、降低血白细胞水平,对Th17/Treg失衡及相关调节因子RORγt和foxp3具有干预作用。
Objective：To investigate the intervention of Chinese herb Shengjiang San（SJS）for the imbalances of Th17/Treg cells and related regulatory factors in sepsis patients.Method：Fifty-five sepsis patients were randomly divided into two groups：conventional group of 27 cases and SJS group of 28 cases.Nine cases of healthy volunteers were enrolled as control group in the study.Cases of conventional group were treated with western medicine only and cases of SJS group were treated with both western medicine and Chinese herb SJS（100ml twice one day）.The therapy course of the three groups was 3days.Score of Chinese medical syndromes,serum level of leukocyte count,C reactive protein（CRP）and procalcitonin（PCT）,RORγt,foxp3,Th17Treg cells in the proportion of whole CD4＋ Th cells and Th17/Treg ratio were compared respectively in each group before and after treatment.Result：There were significant differences between SJS group and conventional group in score of Chinese medical syndromes,serum level of leukocyte count,RORγt,foxp3,Th17Treg cells in the proportion of whole CD4＋ Th cells and Th17/Treg ratio（P〈0.05 or P〈0.01）.There were no significant differences between the two groups in serum level of CRP and PCT.Compared with control group,there were significant differences in all indicators of the two groups（P〈0.01）.Conclusion：Chinese herb Shengjiang San has an effective benefits to Chinese medical syndromes,serum level of leukocyte count,the imbalance of Th17/Treg and related regulatory factors（RORγtfoxp3）in sepsis patients.
出处
《临床急诊杂志》
CAS
2017年第6期406-410,共5页
Journal of Clinical Emergency
基金
上海中医药大学预算内项目(No:2013JW52)
国家中医药管理局重点建设科室(No:ZJ0901JZ015)
国家中医药管理局"全国名老中医专家传承工作室"建设项目(何立人)
