摘要
目的:研究P16、P53、PCNA在膀胱癌中表达及其意义。方法:应用免疫组化S-P法检查52例膀胱癌组织中P53、P16、PCNA表达水平。结果:52例膀胱移行细胞癌中P16、P53、PCNA阳性表达率分别为42.3%5、7.6%、59.6%,P16阳性率在Ⅰ、Ⅱ和Ⅲ级肿瘤中分别为58.8%3、8.5%和22.2%,P53阳性率在Ⅰ、Ⅱ和Ⅲ级肿瘤中分别为41.2%、57.7%和88.9%,PCNA阳性率在Ⅰ、Ⅱ和Ⅲ级肿瘤中分别为17.3%3、0.8%和66.7%;随着膀胱癌病理分级上升,P16表达阳性率逐渐下降,P53和PCNA阳性率逐渐上升。结论:P16、P53、PCNA的免疫组化检测具有评估膀胱癌预后的价值。
Objective： To study the expression and significance of P16,P53 and PCNA in bladder carcinoma.Methods： The immunohisto-chemical staining method was used to evaluate the positivity of P16,P53,PCNA 2 in 52 cases of bladder carcinoma.Results： Of 52 cases,P16 was positive in 22（42.3 %）,P53 was positive in 30（57.6 %）and PCNA positive in 31（59.6 %）.P16 positivity rate in grade I,Ⅱand Ⅲtumors was 58.8 %,38.5 % and 22.2 % respectively;The P53 positivity rate in grade Ⅰ,Ⅱand Ⅲ tumors was 41.2 %,57.7 % and 88.9 %,respectively; The PCNA positivity rate in grade Ⅰ , Ⅱ and Ⅲ tumors was17.3 % ,30.8 %and 66.7 0% respectively. P16 positivity rate was significantly lower in the patients poorly differentiated, but P53 and PCNA positivity rate was significantly higher in the patients poorly differentiated. Conclusion： Immunohisto--chemecal analysis of P16, P53 and PCNA is of some value in evaluating prognosis of bladder cancer.
出处
《包头医学院学报》
CAS
2009年第6期12-13,共2页
Journal of Baotou Medical College
