摘要
目的探讨红芪多糖对膀胱癌大鼠抗肿瘤作用的相关机制研究。方法采用酶联免疫吸附试验法和RT-PCR法,观察不同药物剂量的红芪多糖对膀胱癌大鼠模型血清中VEGF、IL-2和膀胱组织中AQP1和AQP3表达变化的影响。结果红芪多糖对膀胱癌大鼠肿瘤抑制效果以中剂量为佳,其可以提高血清中IL-2含量,减少VEGF含量水平,同时下调AQP1和AQP3基因表达。结论红芪多糖对膀胱癌大鼠的肿瘤生长确实有一定的抑制作用,其机制为增强机体免疫功能,同时其可能通过调节膀胱癌组织AQP1和AQP3,而产生利水渗湿功效,从而达到抑制膀胱癌效果。
Objective To investigate the mechanism of the anti-tumor effect of hedysamn polysaccharide in rats with bladder cancer. Methods ELISA and RT-PCR were used to observe the effect of hedysamn polysaecharide in different dose on the expression ofVEGF, IL-2, AQP1 and AQP3 in rats with bladder cancer. Results Hedysamn polysaccharide in the middle dose has the best effect on bladder cancer rats though increasing the content of IL-2 and reducing the expression ofVEGF, AQP1 and AQP3. Conclusion Hedysamn polysaccharide has a great effect on antitumor in rats with bladder cancer.The mechanism maybe boost immune function, regulate the expression of AQP1 and AQP3 to suppress the growth of cancer cell.
出处
《国外医药（抗生素分册）》
CAS
2015年第1期27-28,共2页
World Notes on Antibiotics
