摘要
目的探讨肿瘤坏死因子a诱导蛋白3（TNFAIP3）基因rs2230926位点多态性与重症肌无力（MG）的关系。方法采用聚合酶链反应-限制性内切酶（PCR—RFLP）技术分析125例MG患者与143名健康对照者rs2230926位点基因型。结果在中国北方地区汉族人群中TNFAIP3rs2230926位点仅有T／T和T／G两个基因型。发病年龄≥40岁的MG患者中T／G基因型及G等位基因出现频率较发病年龄〈40岁的MG患者高（P％0．05）。结论TNFAIP3rs2230926位点与中国北方地区晚发型MG患者发病相关。
Objective necrosis factor alpha induced To analyze the relationships protein 3 （TNFAIP3） rs223 population from North of China. Methods One hundred and fourty-three healthy people were investigated. TNFAIP3 between the polymorphism （SNP） of the tumor 0926 and the myasthenia gravis （MG） in Han twenty five patients with MG and one hundred and gene rs2230926 polymorphism was detected by polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP）. Results Only rs2230926 T/ T and T/G genotype were detected, rs2230926 T/G genotype and G allele were found increased in the patients with a late-onset of disease compared to ones with an early-onset （P〈0.05）. Conclusions TNFAIP3 rs2230926 T/G genotype and G allele may be associated with the late-onset patients.
出处
《中国神经免疫学和神经病学杂志》
CAS
2010年第1期42-45,共4页
Chinese Journal of Neuroimmunology and Neurology
基金
国家自然科学基金资助项目(30700242)
北京市科技新星基金资助项目(2008A87)
关键词
重症肌无力
肿瘤坏死因子α诱导蛋白3
基因多态性
myasthenia gravis
tumor necrosis factor alpha induced protein 3
genetic polymorphism
