摘要
以对羟基苯基丙烯酸为原料,通过羟甲基化得到3-羟甲基-4-羟基苯基丙烯酸,然后对3-羟甲基-4羟基-苯基丙烯酸的双键加成上羟基,再把羧酸还原成醛基,然后与4-苯氧丁基己胺缩合得到亚胺,加氢还原得到目标产物。
The Salmeterol was synthesized through 3-（4-hydroxyphenyl）acrylic acid as started materials. 3-（4-hydroxy-3-（hydroxymethyl）phenyl）acrylic acid was prepared from 3-（4-hydroxyphenyl）acrylic acid through methyloated reaction. Then 3-（4-hydroxy-3-（hydroxymethyl）phenyl）acrylic acid was got from H2O addition reaction wtih double bond to get derivative 3-hydroxy-3-（4-hydroxy-3-（hydroxymethyl）phenyl）propanal. At last, the 3-hydroxy-3-（4-hydroxy-3- （hydroxymethyl）phenyl）propanal react with amino and addition with H2 to get the target compound.
出处
《广东化工》
CAS
2009年第12期58-58,77,共2页
Guangdong Chemical Industry
关键词
沙美特罗
对羟基丙烯酸
合成
Salmeterol
3-（4-hydroxyphenyl）acrylicacid
synthesis
