摘要
Toll样受体(TLRs)是一组天然免疫模式识别受体。其通过启动细胞信号传导途径,激活机体的免疫细胞,触发先天性免疫应答,并对Th1/Th2型获得性免疫的成功诱导起决定性作用。现介绍TLRs在机体免疫应答及哮喘等呼吸道疾病中的免疫调节作用。
Toll - like receptors are an important pattern recognition receptors that recognize specific components of microbes and certain host molecules. Through initiated cell signaling pathway, they can induce immunocyte. Their activation triggers the innate immune response, and is crucial to the successful induction of Th1/Th2 - phenotyped adaptive immunity. This review will give a brief overview of our current knowledge of TLRs as key components in immune responses and their regulation in respiratory tract diseases such as asthma.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2009年第21期1685-1688,共4页
Journal of Applied Clinical Pediatrics
关键词
TOLL样受体
信号传导
免疫应答
哮喘
toll - like receptors
signal transduction
immune responses
asthma
