摘要
近年来,哮喘的发病率和病死率逐年升高,尤其是哮喘的急性发作和加重已经成为哮喘患儿住院和死亡的主要原因。哮喘的急性发作和加重最重要原因之一是病毒性呼吸道感染,鼻病毒作为呼吸道感染最常见的病原体可触发哮喘的急性发作。鼻病毒引起哮喘发作的病理机制主要包括炎症介质的释放,Th1/Th2型免疫反应失衡及气道重塑,但鼻病毒感染引发哮喘急性发作和加重的病理机制还有待进一步探讨。
The morbidity and mortality of asthma are increasing year by year, particularly the acute asthma attacks and exacerbations are associated with the most of hospitalization and death. Viral respiratory tract infections are the main causes of the acute asthma attacks and exacerbations, and the most common pathogens are rhinoviruses. The pathologic mechanism of rhinoviruses induced asthma mainly includes the releasing of inflammatory mediators, the imbalance of Th1/ Th2 immune responses and the rebuilding of respiratory tract. However, future studies are required to investigate the pathologic mechanism.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2009年第7期689-691,共3页
Journal of Clinical Pediatrics
关键词
鼻病毒
哮喘
急性加重
rhinovirus
asthma
acute exacerbations
