摘要
目的探讨富硒蛹虫草的降血脂和抗氧化作用。方法昆明种雄性小鼠60只,随机分4组(n=15只/组):正常对照组、高脂模型组、普通蛹虫草组、富硒蛹虫草组。用不同的饲料持续喂养5周,每周的固定时间称量小鼠体质量1次,第5周断头取血后解剖小鼠,检测血清总胆固醇(T-CHO)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及肝组织谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)和丙二醛(MDA)含量。结果富硒蛹虫草组与高脂模型组相比,T-CHO和TG的含量降低,HDL-C的含量升高,均达到了显著水平(P<0.05);LDL-C含量降低(P>0.05);GSH-Px和SOD活性升高,MDA含量降低,均达到了显著水平(P<0.05)。并且富硒蛹虫草的降血脂与抗氧化作用均高于普通蛹虫草。结论富硒蛹虫草具有良好的降血脂和抗氧化作用。
Objective To discuss the hypolipidemic and anti - oxidant effect of Se - enrich C. militaris. Methods Sixty kunming male mice were randomly assigned to four groups （n = 15 in each group） ： base control group, high lipid model group, ordinary C. militaris group, Se - enrich C. militaris group. With different feed continuous feeding for five weeks, the body weights of mice were weighed at fixed - time weekly. In the fifth week, the mice were decapitated after taking out the blood from mice. The total cholesterol（ T - CHO）, triglyeride （ TG）, high - density lipoprotein cholesterol （ HDL - C ）, low - density lipoprotein cholesterol （ LDL - C ） of serum and the glutathione peroxidase （ GSH - Px）, superoxide dismutase （ SOD）, malondialdehyde （MDA） of liver tissue were measured. Results Compared Se - enrich C. militaris group to high lipid model group, T - CHO and TG content decreased, HDL - C content increased to significant levels （ P 〈 0.05 ） ; LDL - C content decreased （ P 〉 0.05 ）. GSH - Px and SOD activity increased, MDA content decreased to a significant level （P 〈 0.05）. And Se - enrich C. militaris of hypolipidemic and anti - oxidant were higher than ordinary C. rnilitaris. Conclusion Se - enrich C. militaris has good hypolipidemic and anti - oxidant effect.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第12期3142-3144,共3页
Lishizhen Medicine and Materia Medica Research
关键词
蛹虫草
硒
降血脂
抗氧化
Cordyceps militaris （ Fr. ） Link
Selenium
Hypolipidemic
Anti - oxidant
