摘要
目的探讨三阴性乳腺癌患者的临床病理特点、分子生物学特性、生存率以及影响预后的因素。方法回顾性分析44例三阴性乳腺癌患者的病历资料,分析其临床病理特点、分子生物学指标和各种治疗方式对生存的影响。结果全组44例患者均为女性,占同期收治乳腺癌患者的7.0%,中位年龄49岁（35-82岁）。其中,浸润性导管癌31例（70.5%）,单纯癌6例（13.6%）,髓样癌3例（6.8%）,管状腺癌2例（4.5%）,导管内癌2例（4.5%）。Ⅰ期患者6例（13.6%）,Ⅱ期19例（43.2%）,Ⅲ期17例（38.6%）,Ⅳ期2例（4.5%）。核分级Ⅰ级6例（13.6%）,Ⅱ级15例（34.1%）,Ⅲ级23例（52.3%）。伴有脉管瘤栓22例（50%）,伴有神经浸润10例（22.7%）。中位生存时间4.0年（1.5-8.5年）。单因素分析结果显示,影响总生存的因素为肿瘤大小、淋巴结状态、临床分期、脉管瘤栓和神经浸润。多因素分析结果显示,肿瘤大小和淋巴结状态是影响预后的独立因素。3年总生存率是66.7%。结论三阴性乳腺癌发病率较低,组织学分级较高,多为浸润性导管癌,易较早出现复发和转移。影响总生存的因素为肿瘤大小、淋巴结状态、临床分期、脉管瘤栓和神经浸润，其中影响预后的独立因素是肿瘤大小和淋巴结状态。
Objective To analyze the clinicopathological features,parameters of molecular biology,survival rate,and prognostic factors in triple-negative breast cancer patients.Methods The data of 44 triple-negative breast cancer patients between February 2002 and June 2007 in our institution were retrospectively analyzed.Clinicopathological characteristics,parameters of molecular biology and overall survival rate were surveyed.Results Of all breast cancer patients registered in our institution during this period,these 44 triple-negative breast cancer accounted for 7. 0% with a median age of 49 years （35 - 82years）. The pathologi- cal types were infitrating ductal carcinoma （ 70. 5 % ）, simple carcinoma （ 13. 6% ）, mye carcinoma （ 6. 8% ）, tubular adenocarcinoma（4. 5% ） ,intraductal carcinoma（4. 5% ）. The stages included stage-Ⅰ 13.6%, stage-Ⅱ 43.2%, stage-Ⅲ38.6% and stage-Ⅳ 4. 5%. The patients with vaseular invasion accounted for 50%, and with nerve invasion accounted for 22. 7%. The median survival time was 4. 0 years（ 1.5-8. 5 years）. The factors which were found to compromise overall survival were tumor size, lymph node status, clinical stage, vascular invasion and nerve invasion in the univariate analysis. Tumor size and lymph node status were found to be independent prognostic factors for overall survival in the multivariate analysis. The 3-year overall survival rate was 66. 7%. Conclusion Patients with triple-negative breast cancer had low incidence rates, high histological grade and high rate of local and systemic relapse. The maior pathological type was infitratinK ductal carcinoma. The factors which were found to compromise overall survival were turner size, lymph node status, clini- cal stage, vascular invasion and nerve invasion in the univariate analysis. Tumor size and lymph node status were found to be independent prognostic factors for overall survival in the multivariate analysis.
出处
《中国肿瘤临床与康复》
2009年第5期392-395,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
乳腺肿瘤
临床病理特点
预后因素
Breast neoplasms
Clinicopathologic characteristics
Prognostic factors
