摘要
目的 探讨20～40岁青年肾细胞癌患者的临床病理特点、治疗效果及预后影响因素.方法 回顾性分析2001年1月至2011年5月接受手术治疗的128例青年肾细胞癌患者的临床资料.男82例,女46例.就诊时无明显症状者94例（73.4％）.肿瘤最大径≤4 cm 54例（42.2％）,＞4～7 cm 57例（44.5％）,＞7 cm 17例（13.3％）.临床分期T1期111例（86.7％）,T2期17例（13.3％）. 结果 128例手术均获成功.肿瘤病理类型以肾透明细胞癌（83例,64.8％）为主,分级以高分化癌（121例,94.5％）为主.术后1年、5年肿瘤特异性生存率分别为100％和96％.Log-rank检验分析显示,Fuhrman细胞核分级、肿瘤病理类型及临床分期与预后密切相关（P＜0.05）. 结论 青年肾细胞癌病理类型以高分化、透明细胞癌为主,手术治疗效果及总体预后良好.Fuhrman细胞核分级、肿瘤病理类型及临床分期是影响青年肾细胞癌患者预后的独立危险因素.
Objective To analyze the clinical pathological characteristics and prognosis of renal cell carcinoma （RCC） in adults aged 20-40 years.Methods The data of 128 young RCC （aged 20-40 years） from January 2001 to May 2011 were retrospectively analyzed.There were 82 males and 46 females,and 94 cases （73.4%） were asymptomatic.The clinical stage was T1 in 111 cases （86.7%） and T2 in 17 cases （13.3%）.Results Surgical treatment of 128 patients was successful.The most frequent histological type was renal clear cell carcinoma （64.8%）,and differentiation of most tumor was good （94.5%）.The cancer-specific survival rates at 1-and 5-year were 100% and 96%,respectively.Independent prognostic factors were tumor differentiation,pathological types and tumor stage （P〈0.05）.Conclusions Well differentiation is most common in adults aged 20-40 years with RCC and the patients have good prognosis.Tumor differentiation,pathological types,tumor stages are independent prognostic factors for survival.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2014年第10期731-733,共3页
Chinese Journal of Urology
关键词
癌
肾细胞
青年
保留肾单位手术
根治性肾切除术
预后
Carcinoma, renal cell
Young
Nephron sparing surgery
Radical nephrectomy
Prognosis
