摘要
目的观察静脉注射氨茶碱对芬太尼诱发咳嗽反应的影响。方法200例择期手术,ASA I～Ⅱ级,年龄18～72岁,随机均分为氨茶碱组(A组)和安慰剂组(P组)。诱导前上肢静注氨茶碱1mg/kg(A组)或0.9%生理盐水(P组)2mL,1min后静推给芬太尼3μg/kg,记录咳嗽发生时机、次数及程度。结果氨茶碱组咳嗽发生率明显低于安慰剂组(3%vs40%,P<0.01),且发生时机延迟(P<0.01)。结论静脉注射氨茶碱可抑制芬太尼诱导的咳嗽反应发生率,且发生时机延迟。
Objective To study the effects of intravenous aminophylline on fentanyl-induced cough.Methods 400 patients ASA Ⅲ,18-68yr were divide equally into aminophylline group（group A）and placebo group（group P）,All patients were adminised IV aminophylline 1mg/kg（group A） or equal volume of 0.9% saline（group P）before Ⅳ fentanyl 3 μ g/kg at 0.1mg/s.Recorded the number of episodes of coughing,and severity of coughing.Results After the intravenous injection of fentanyl bolus,patients in group A showed significantly higher frequency cough than those in group P（8%vs 40%,P〈~0.01）,and onset time in group A was significantly longer than that in group P（P〈：0.01）However, no difference in cough severity was observed between the two groups. Conclusion Low-dose aminophylline（1mg/kg Ⅳ）effectively reduces fentanyl-induced cough and delays the onset time of cough.
出处
《中外医疗》
2009年第33期86-87,共2页
China & Foreign Medical Treatment
关键词
氨茶碱
芬太尼
咳嗽
抑制
Aminophylline
Fentanyl
Cough
Suppress
