摘要
目的探索缺血修饰白蛋白对心肌缺血的诊断价值。方法根据临床体征和心电图检查把病人血清分为心肌缺血病人组与非心肌缺血病人组,心肌缺血组病人48例,非心肌缺血组病人134例,同时选取30例正常健康人血清作为对照组。采用白蛋白-钴结合试验对缺血修饰白蛋白进行检测,测定结果以ACB单位报告,ACB单位的降低反映了IMA水平的升高,具有临床意义。并采用SPSS13.0软件对检测结果进行统计学分析。结果三组标本检测的ACB值呈梯度分布,心肌缺血组ACB的值明显低于非心肌缺血组和健康对照组,而非心肌缺血病人组的ACB值又明显低于健康对照组,均有显著性差异。48例缺血组病人的五种心肌缺血生化标志物的检测中,IMA阳性率和阳性例数明显高于其他四种(LDH,CK,CK-MB,MB)生化指标。结论缺血修饰白蛋白是急性心肌缺血早期,灵敏及特异的生化标志物。
Objective To understand the diagnostic significance of ischemia modified albumin （IMA） in the diagnosis of acute myocardial ischemia（AMI）. Methods 48 patients with myocardial ischemia, 134 non-myocardial ischemia patients, and 30 healthy people were selected to detect serum ischemia modified albumin （IMA） by albumin cobalt binding assay （ACB）. SPSS 13.0 software was used to analyze test results. Results ACB value of myocardial ischemia group was significantly lower than that of the non-myocardial ischemia group or the control group. IMA positive rate and number were higher than those of LDH, CK, CK-MB, MB in this patient group. Conclusions Isehemia modified albumin is a early, sensitive and specific biochemical indicator for the judgment of acute myocardial ischemia.
出处
《实验与检验医学》
CAS
2009年第5期448-450,468,共4页
Experimental and Laboratory Medicine
