摘要
1型糖尿病是遗传易感体在免疫介导的作用下选择性损伤分泌胰岛素的胰岛β细胞为亚临床特征的一种慢性疾病,其中CD4+和CD8+T淋巴细胞对胰岛β细胞的浸润和破坏起着重要的作用,而B淋巴细胞、自然杀伤细胞、树突状细胞在1型糖尿病发病机制中的作用也不容忽视。
Type 1 diabetes（T1D）is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta-cells in the pancreatic islets in genetically susceptible subjects.Autoreactive T cells,both CD4＋ and CD8＋ T lymph cells,have been implicated as active players in beta-cell destruction,simultaneously the B lymphocyte,the NK cell and the Dendritical cells are also playing vital role in 1 diabetes pathogenesis.
出处
《医学综述》
2009年第19期2994-2997,共4页
Medical Recapitulate
