摘要
人体内的葡萄糖平衡受胰岛α细胞所分泌的胰高血糖素(GCG)和胰岛β细胞所分泌的胰岛素的调节。而糖尿病的发生,则主要是由于胰岛素缺陷或是IR导致,与此同时,GCG的分泌绝对过多或是相对过多在其中具有重要的影响。以往临床研究则主要集中于胰岛β细胞,而对于胰岛α细胞的研究则相对较少。实际上,糖尿病患者空腹血糖(FPG)与餐后2 h血糖(PPG)的升高与其GCG血症具有密切联系,GCG参与了糖尿病的病理与生理过程,当胰岛α细胞功能出现异常时,会导致其机体对低血糖的反应能力下降,故而其与糖尿病的发生以及发展密切相关。因此,本文就胰岛α细胞在糖尿病发病及其治疗领域中的研究进行综述。
Glucose balance in human body is regulated by glucagon GCGs secreted by islet α cells and insulin secreted by islet β cells.The development of diabetes is mainly due to insulin deficiency or IR, at the same time, the absolute or relatively excessive secretion of GCG plays an important role in it.Previous clinical studies mainly focus on islet β - cells, but relatively few on islet α - cells.In fact, the increase of fasting blood glucose （FBG） and 2 h postprandial blood glucose （PPG） in diabetic patients is closely related with their GCG.When the function of the islet alpha cells are abnormal,this the pathological and physiological processes will lead to a decline in the body s ability to respond to hypoglycemia, so it is closely related with the occurrence and development of diabetes.Therefore, the article reviews the research of the islet alpha cells in the field of diabetes and its treatment.
作者
王莎莎
WANG Sha-sha(Department of Diabetes,Nankai District Traditional Chinese Medicine Hospital,Tianjin,300102,China)
出处
《黑龙江医学》
2018年第9期933-935,共3页
Heilongjiang Medical Journal
