摘要
探讨复相乳液法制备聚乳酸(PLA)/胰岛素缓释微胶囊的制备工艺.以聚乳酸为包裹载体,胰岛素为模型药物,通过复相乳液法制备出胰岛素缓释微胶囊,通过考察稳定剂、超声时间及功率、搅拌速度、聚乳酸分子量等条件对粒径大小及其分布、表面形态的影响,初步探讨了聚乳酸包裹胰岛素微胶囊的制备工艺.经粒度分析仪、扫描电镜、激光共聚焦显微镜观察结果显示,制备的微胶囊表面光滑圆整,平均粒径在4μm左右.复相乳液法制备载药微球工艺简单,乳液稳定性好,可以负载具有生物活性的药物.
Preparation of polylactide/Insulin Sustained-release Microcapsules with diphase emulsion method was studied. Microcapsules were prepared using polylactide as carrier and insulin as model drug. The factors influencing the particle sizes, surface topography and preparation technology such as stabilizer, ultrasonic time, ultrasonic power, and mixing rate were discussed. The surface of the particles was smooth, the average size was about 4μm. The preparation techniques of drug-loading system are simple and the emulsion is stable. This method can be used to prepare the bioactive drugs carrier.
出处
《西安工业大学学报》
CAS
2009年第4期341-344,共4页
Journal of Xi’an Technological University
基金
陕西省教育厅重点科学研究计划(08JK308)
关键词
微胶囊
缓释
聚乳酸
复相乳液法
microcapsule
sustained-release
poly（lactide）
diphase emulsion method
