摘要
介绍了一种新型的聚乙烯醇凝胶辅助法（PAF）来制备三维互联大孔羟基磷灰石（HA）陶瓷,PAF法不涉及模板剂、造孔剂的使用及复杂化学过程.X射线衍射分析表明：经烧结后的HA组分单一,为纯HA.扫描电子显微镜（SEM）和激光共聚焦显微镜观察结果表明：大孔HA孔结构的联通性和孔径大小可通过控制HA粉及PVA的用量来实现;当PVA与HA质量比为4.4和4.9时制得的大孔HA孔径分布较均匀,所制得大孔HA具有三维互联结构,大孔直径介于90~200μm,较接近人骨的孔尺寸和联通特性,具有潜在的应用价值.
A novel synthesis method,called poly（vinyl alcohol） assisted foaming method（PAF method） for the preparation of porous hydroxyapatite（HA） scaffolds with 3D-interconnected macropores without using any templates or porogens or complicated chemical process was reported.XRD analyses revealed that the sintered macroporous HA is pure in compositions.SEM and CLSM results showed that the macroporous structures and pore sizes can be facilely tuned by adjusting the mass ratios of PVA to HA.The mass ratios PVA to HA of 4.4 and 4.9 produce macroporous HAs with uniformly distributed macropores with sizes ranging from 90 to 200 μm in sizes,which are similar to those of human bone in terms of macropore size and interconnectivity.It is therefore believed that such kind of 3D interconnected macroporous HA scaffolds have great potential for application in the area of bone tissue engineering.
出处
《东北大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2011年第11期1587-1590,共4页
Journal of Northeastern University(Natural Science)
基金
国家高技术研究发展计划项目(2009AA03250)
中央高校基本科研业务费专项资金资助项目(N100302001)
国家自然科学基金资助项目(50872018
50902018)
教育部创新团队发展计划项目(IRT0713)
关键词
无模板法
大孔
羟基磷灰石
三维互联
non-templated
macroporous
hydroxyapatite
3D-interconnected
