摘要
光动力治疗(photodynamic therapy,PDT)是光敏剂在特定波长光源的激发下、在氧分子存在下产生细胞毒性物质的一种治疗方法,主要用于抗肿瘤治疗.目前临床应用的光敏剂对肿瘤细胞的靶向性比较有限,近来的一个热门研究方向是靶向性光敏剂.结合作者多年来在该方向的工作,综合近年来光敏剂研究的发展,比较全面地阐述了带有功能性多肽的靶向性光敏剂及其在光动力治疗中的应用.阐述多肽作为靶向基团的优势,总结了包括透膜多肽、血管靶向多肽、细胞受体靶向多肽等功能多肽与光敏剂偶合物的生物效应,说明了多肽能够实现光敏剂的靶向作用.
Photodynamic therapy （PDT） relies on the interaction of light, photosensitizer, and the presence of oxygen, leading to cytotoxicity to the tissue containing the photosensitizer. The tissue specificity of photosensitizer is thus one of the key factors in photodynamic therapy. The limited targeting capability of current photosensitizers that are in the clinical applications has led to the active development of the new generation of photosensitizer. Another approach-peptide conjugation-to enhance the tissue specificity of photosensitizers were reviewed. The cell penetrating peptides, vasculature targeting peptides, and peptides targeting cell surface receptors were reviewed. The current research indicates that the effectiveness of peptide conjugation to confer the tissue specificity to photosensitizers.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2009年第9期1106-1113,共8页
Progress In Biochemistry and Biophysics
基金
国家高技术研究发展计划(863)(2006AA02A313)
国家自然科学青年科学基金(30625011)资助项目~~
关键词
光动力治疗
光敏剂
肿瘤
靶向性
多肽
photodynamic therapy, photosensitizer, cancer, targeted, peptide
