摘要
目的探讨2型糖尿病(T2DM)患者血清Cysc和hs-CRP的水平对诊断糖尿病早期肾损害的价值。方法T2DM患者根据其肾功能分为肾功能正常组和肾功能异常组,各30例,同时选择30例健康者为对照组。比较各组血清CysC以及hs-CRP水平。结果T2DM患者CysC以及hs-CRP水平均高于对照组(P<0.05),肾功能异常组患者的CysC以及hs-CRP水平也明显高于肾功能正常组(P<0.05);在T2DM患者中,血清CysC与hs-CRP呈正相关(r=0.39)。结论CysC和hs-CRP作为诊断糖尿病早期肾损害的敏感指标,联合检测更具价值。
Objective Methods To evaluate the clinical value of the levels of serum cystatin C （CysC） and high sensitive C - reactive （hs - CRP） protein in diagnosing Type 2 diabetes mellitus （T2DM） patients with early renal injury. Methods According to the renal function indice（including creatinine and blood urea nitrogen）, 60 patients with T2DM were divided into two groups ： the normal renal function group（n= 30）and the abnormal renal functlon group（n= 30）. Another 30 health people served as the control group. The levels of serum Cys C and hs - CRP were examined. Results The levels of serum Cys C and hs- CRP in patients with T2DM were significantly higher than those in the control group（ P 〈 0.01 ）, while the levels of serum Cys C and hs- CRP in abnormal renal function group also significantly higher than those in the normal renal function group（ P 〈0.01）. The level of serum CysC was positively correlated with the level of hs- CRP（r= 0.39）in T2DM patients. Conclusion CysC and hs - CRP may be used as sensitive indexes of diagnosing early renal injury in type 2 diabetes mellitus. Combined examination can have more practical value.
出处
《山东医学高等专科学校学报》
2009年第5期381-382,共2页
Journal of Shandong Medical College
关键词
胱抑素C
超敏-C反应蛋白
糖尿病
肾损害
并发症
Cystatin C
High sensitive C- reactive protein
Diabetes mellitus
Renal injury
Complications
