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胱氨酸蛋白酶抑制剂C的临床应用 被引量:64

Clinical application of cystatin C
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摘要 目的 进一步证实血清胱氨酸蛋白酶抑制剂C在评价肾小球滤过功能方面的价值。方法 用颗粒增强散射免疫比浊法检测 1 6 4例肾脏损害患者血清胱氨酸蛋白酶抑制剂C的浓度 ,并与其血清尿素、肌酐、内生肌酐清除率相比较。结果 胱氨酸蛋白酶抑制剂C与内生肌酐清除率之间高度相关 (P <0 .0 1 )。结论 胱氨酸蛋白酶抑制剂C是一种理想的反映肾小球滤过率 (GFR)的标志物 。 Objective To further confirm the value of Serum Cystatin C on the filtration function.Methods Serum Cystatin C concentrations were measured in 164 patients suffered from renal lesions using a particle-enhanced nephelometric assay . The results were compared with blood urea ,Scr and Ccr.Results The study showed that there was a high relativity between Cystatin C and Ccr.Conclusion Cystatin C may be an ideal marker of GFR, and Cystatin C assay may be used as a novel method for the purpose of evaluating glomerular filtration.
作者 李晓娟
出处 《国外医学(临床生物化学与检验学分册)》 2004年第1期6-7,共2页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 胱氨酸蛋白酶抑制剂C 临床应用 内生肌酐清除率 肾小球滤过率 肾脏疾病 Cystatin C endogenous creatinine clearance rate glomerular filtration rate (GFR)
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  • 1Andersen JK,Schmidt C,Nordin G.Serum cystatin C.determined by a rapid,automated particle-enhanced turbidimetric method,is a better marker than serum cretinine for glomerular filtration rate.Clin Chem,1994,40(10):1921-1926. 被引量:1
  • 2Randers E,Erlandsen EJ.Serum cystatin C as endogenous marker of the renal function-a review.ClinChem Lab Med,1999,37(4):389-395. 被引量:1
  • 3keevil GB,Kilpatrick ES,Nichols SP,et al.Biological variation of cystatin C:implication for the assessnent of glomerular filtration rate.Clin chem.1998,44(7):1535-1539. 被引量:1
  • 4Finney H,Newman DJ,Gruber W.Initial evaluatin of cystatin C measurement by particle-enhanced immunonephelometry on the Behring nephelometer systems(BNA,BN Ⅱ).Clin Chem,1997,43(6):1016-1020. 被引量:1

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