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血浆纤维蛋白原与动脉粥样硬化:值得关注的缺血性卒中治疗靶点 被引量:7

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摘要 关于缺血性卒中急性期治疗,发病3h内重组组织型纤溶酶原激活剂(recombinant human tissue-type plasminogen activator,rtPA)溶栓、阿司匹林抗血小板聚集治疗均取得了较为安全有效的结果。动脉粥样硬化是缺血性卒中最重要的病理基础,大量研究已证实血浆纤维蛋白原及其降解产物在动脉粥样硬化进程中起了非常重要的作用,高纤维蛋白血症(hyperfibrinogenmia)是卒中的独立危险因素,其升高与缺血性卒中的不良预后关系密切。因此,血浆纤维蛋白原应该是一个值得关注的缺血性卒中治疗靶点。尽管目前关于缺血性卒中的降纤治疗还存在不少争议。
作者 刘春风
出处 《中国卒中杂志》 2009年第8期617-620,共4页 Chinese Journal of Stroke
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参考文献11

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