摘要
目的 观察降纤酶治疗冠心病伴高纤维蛋白原血症的效果。方法 治疗组 :冠心病伴高纤维蛋白原血症 2 7例 ,应用降纤酶 10U、5U、5U用生理盐水 10 0～ 2 0 0ml稀释静滴 ,隔日 1次。对照组 16例采用复方丹参注射液 2 0ml/d稀释静滴 ,10d为 1个疗程。结果 降纤酶和丹参对心绞痛等症状的有效率分别为 88.89%和 87.5 0 % ;对心电图缺血型ST -T的有效率为 6 2 .96 %和 43.75 % ;对血流变的作用 ,降纤酶能非常显著地降低全血低切粘度、高切粘度、全血还原高切粘度、血浆粘度、纤维蛋白原 ,血沉方程K值 (P <0 .0 0 1) ,并显著降低全血还原低切粘度、血沉、RBC聚集指数和电泳指数 (P <0 .0 1) ,而对RBC刚性指数和变形指数无明显影响 (P >0 .0 5 )。而丹参仅能降低全血低切、高切粘度、纤维蛋白原和RBC聚集指数 (P <0 .0 1,P <0 .0 5 ) ,而对其它血流变指标无明显作用(P >0 .0 5 )。结论 降纤酶治疗冠心病伴高纤维蛋白原血症有明显疗效 。
Objective To investigate the effect of Defibrase (DF) on treatment of CHD with pyperfibrinogenemia.Method DF was used to treat 27 patients with CHD and hyperfibrinogenemia,with the dose of 10U,5U,5U,qod;in Danshen group (16 patients with slient myocardial),20ml/d,iv,for 10 days.Results The results were as follows:the effective rates in the treatment of the signs of angina and so on were 88.98% (DF group) and 87.50% (Danshen group);the effective rate in that of ischemic ST-T of ECG were 62.96% (DF group) and 43.75% (Danshen group).so far as effect on the indices of hemorheology,DF was concerned effectiveness was obviously better than Danshen effect,the former could remarkably reduce ηBL,ηBH,Pfc,ηP,ηrH,ηrl,EAI and so on ( P<0.001,P<0.01 ),but had no effect on ERI the latter only reduced ηrl,ηBH,PFC and EAI ( P<0.01,P<0.05 ),especially had the effects on Fg in Df group's Fg decreased from 3.91 to 1.61g/L( P <0.001),while in Danshen from 3.77 to 3.48g/L( P <0.05).Conclusion DF has obvious effect on CHD with hyperfibinogenemia,and DF's effectiveness was better than Danshen's.
出处
《苏州医学院学报》
2000年第9期819-821,共3页
Acta Academiae Medicinae Suzhou
关键词
降纤酶
冠心病
高纤维蛋白原血症
治疗
defibrase
coronary
heart disease
hyperfibrinogenemia clinical study
