摘要
目的:探讨慢性阻塞性肺疾病急性加重期(AECOPD)痰热证模型大鼠血浆内皮素(ET)及降钙素基因相关肽(CGRP)的变化及通塞颗粒的作用。方法:通过烟熏、滴菌结合风热刺激的方法建立AECOPD痰热证大鼠模型。采用非平衡法测定血浆ET、CGRP含量。结果:模型组较正常组ET升高(P<0.01),CGRP下降(P<0.05);通塞颗粒组ET较模型组降低(P<0.05),CGRP升高(P<0.05)。结论:ET、CGRP参与了AECOPD的病理生理过程,调节血浆中ET、CGRP的水平可能是通塞颗粒治疗COPD的作用机制之一。
Objective： To approach the change of CGRP and plasma ET in rat＇ s model of sputum - pyretic syndrome in chronic obstructive pulmonary diseases acute exacerbation and action of Tongsai granula. Methods ： By smoking and bead bacterium and united wind heat stimulation to setup rat＇ s model of phlegm and pyretic syndrome of AECOPD. Assay content of plasma ET and CGRP with imbalance method. Results： ET in model team is higher than in common team（ P 〈 0.01 ） ,CGRP in model team is lower（ P 〈0.05 ）, ET in Tongsai granula team is lower than model team （ P 〈 0.05 ）, CGRP is higher （ P 〈 0.05 ）. Conclusion ： ET and CGRP participated the pathophysiology processes of AECOPD, one of the mechanism of action of Tongsai granula to treat COPD is adjusting level of plasma ET and CGRP.
出处
《河南中医学院学报》
2009年第5期25-26,共2页
Journal of Henan University of Chinese Medicine
基金
国家自然科学基金(编号:30772797)
河南省高校新世纪优秀人才支持计划(编号:2006HANCET-05)
