摘要
目的探讨抗结核药物所致肝损害的特点及危险因素。方法于2002年1月至2007年12月在我院确诊的初治肺结核患者共367例,应用2H3R3E3Z3/2H3R、2HREZ/2H3R3及9PaDE三种方案抗结核治疗,每半月查肝功能一次。结果采用9PaDE方案治疗者其肝损害发生率较采用其他二种方案者差异显著,在单因素分析中,既往有肝病史、糖尿病史、酒精依赖、年龄>65岁等因素有显著意义。结论药物性肝损的危险因素患者应采用个体化治疗方案,以减少肝损的发生。
Objective To discuss and analyze characteristics and risk factors of anti-tuberculosis drug-induced liver damage, and to provide a basis for the rational use. Methods 367 cases from January 2002 to December 2007 in our hospital of the early diagnosis of pulmonary tuberculosis had the application 2H3 R3 E3 Z3/2H3 R, 2 HREZ/2 H3 R3 and 9 PaDE of three anti-tuberculosis treatment program, with measures of liver function, a half months each time. Results Use of 9PaDE showed difference the incidence of liver damage than the use of 2H3 R3 E3Z3/2H3 R, 2HREZ/2H3 R3. In the single-factor analysis, the related factors were the past history of liver disease, diabetes, history of alcohol dependence, more than 65 years of age, among others. Conclusion The patients should receive individualized treatment programs to reduce the anti-tuberculosis drug-induced liver damage.
出处
《临床肺科杂志》
2009年第9期1168-1169,共2页
Journal of Clinical Pulmonary Medicine
关键词
肺结核
化学疗法
肝损害
pulmonarytuberculosis
drug therapy
liver injury
