摘要
目的探讨脂质代谢与糖尿病视网膜病变之间的关系。方法检测１６８例糖尿病病人血清中的总胆固醇（ＣＨ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、载脂蛋白Ａ１（ＡｐｏＡ１）、载脂蛋白Ｂ１００（ＡｐｏＢ１００）和脂蛋白（ａ）［Ｌｐ（ａ）］；并同时观察这些病人的视网膜情况。结果伴有糖尿病视网膜病变的病人血清中的总胆固醇、ＬＤＬ－Ｃ和Ｌｐ（ａ）较不伴有糖尿病视网膜病变的病人明显增高，而ＨＤＬ－Ｃ、ＡｐｏＡ１和ＡｐｏＡ１／ＡｐｏＢ１００比例则较无糖尿病视网膜病变的病人明显降低。经Ｌｏｇｉｓｔｉｃ回归分析，总胆固醇、ＨＤＬ－Ｃ和ＡｐｏＡ１／ＡｐｏＢ１００作为独立的因素仍然与糖尿病视网膜病变相关。结论脂质代谢的异常，可能是糖尿病视网膜病变发生和加重的重要因素。
おURPOSE To investigate the relationship between lipid metabolism and diabetic retinopathy.METHODS Levels of serum total cholesterol(CH), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C),Apo-protein Al(ApoA1),Apo-protein B100 (ApoB100), ApoA1/ApoB100 ratio,lipoprotein(a) , levels were compared between 168 patients with and without diabetic retinopathy.RESULTS We found that CH, LDL-C and Lp(a) levels were obviously high and HDL-C, ApoA1 and ApoA1/ApoB100 levels were obviously low in diabetic retinopathy patient group. After logistic regression analysis, CH, HDL-C and ApoA1/ApoB100 as independent factors were still correlated with diabetic retinopathy.CONCLUSIONS Abnormal serum lipid levels may play an important role in the generation and deterioration of diabetic retinopathy.
出处
《上海医科大学学报》
CSCD
1998年第4期297-300,共4页
Journal of Fudan University(Medical Science)
关键词
糖尿病
视网膜病变
脂质代谢
diabetic retinopathy
total cholesterol
triglyceride
high density lipoprotein cholesterol
low density lipoprotein cholesterol
Apo-protein A1
Apo-protein B100
lipoprotein(a)
