摘要
表皮生长因子受体(epidermal growth factor receptor,EGFR)为典型的受体酪氨酸激酶,能够与多种配体结合,在细胞增殖、存活、黏附、分化和凋亡等生命活动中发挥重要作用。EGFR及其介导的信号通路的异常与肿瘤的发生发展密切相关。很多环境理化因素可通过影响EGFR磷酸化、或其结构功能和细胞分布、或其配体和其它相关分子表达,干预EGFR信号转导过程、影响靶基因的表达从而最终影响细胞生命活动。文中就此做一简要综述,以期更好地理解环境理化因素引起的细胞应激以及致突变致癌的表遗传分子机理。
Epidermal growth factor receptor （EGFR）is a classic protein tyrosine kinase receptor ,which plays an important role in cell proliferation ,survival ,adhesion ,differentiation and apoptosis. Abnormality of EGFR and its signaling are closely associated with tumor initiation and development. Many environmental physical and chemical agents can interfere with EGFR and its signal transduction pathways via affecting its phosphorylation, conformation and function, or distribution on cell membrane, finally influencing gene expression and cell fate. This review focuses on the recent progress of above aspects for further understanding of epigenetic mechanisms of cellular stress and carcinogenesis related with environmental agents.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2009年第3期320-327,332,共9页
Journal of Zhejiang University(Medical Sciences)
基金
国家自然科学基金项目(30770831
30500413)
国家基础科学人才培养基金项目(J0730856)
浙江省自然科学基金人才项目(R207153)
关键词
受体
表皮生长因子
化学
分析
致癌物
衔接蛋白质类
信号转导
受体蛋白质酪氨酸激酶类
Receptor,epidermal growth proteins ,signal transducing factor
Chemistry, analytical
Carcinogens
Adaptor Receptor protein-tyrosine kinases
