摘要
目的探讨老年肺癌组织表皮生长因子受体(EGFR)突变影响因素及与肿瘤病理学特征相关性。方法回顾性分析264例肺癌组织样本,收集所有患者临床资料,采用荧光PCR检测EGFR突变,并从临床病理类型、浸润程度比较突变率;在影响因素上从吸烟、淋巴结转移、临床分期、胸膜侵犯、性别、年龄、肿瘤部位、肿瘤直径、基础疾病、病程、家族史、既往肺部疾患进行比较,非条件Logistic回归进行独立危险因素总结。结果①腺癌EGFR突变率57.59%,远高于其他病理类型比率(P<0.05),在肺腺癌浸润程度中,浸润性肺腺癌EGFR突变率66.9%,远高于其他浸润程度肺腺癌(P<0.05)。②老年EGFR突变单危险影响因素有吸烟、淋巴结转移、临床分期(Ⅲ~Ⅳ期)、胸膜侵犯、女性(P<0.05),而与年龄、肿瘤部位、肿瘤直径、基础疾病、病程、家族史、既往肺部疾患无关(P>0.05)。③非条件Logistic回归分析,吸烟、淋巴结转移、临床分期、胸膜侵犯、女性是老年EGFR突变独立影响因素(P<0.05)。结论EGFR突变和肺癌患者病理资料、性别、吸烟、淋巴结转移、临床分期等均有关,肺腺癌EGFR突变和浸润程度相关性强。
Objective To investigate the factors influencing the mutation of epidermal growth factor receptor(EGFR)in elderly lung cancer tissues and its correlation with the pathological characteristics of tumors.Methods 264 lung cancer tissue samples were retrospectively analyzed.Clinical data of all patients were collected.EGFR mutations were detected by fluorescent PCR,and the mutation rates were compared from clinicopathological type and infiltration course.Influencing factors included smoking,lymph node metastasis,clinical stage,pleural invasion,sex,age and location of tumors.The diameter of tumors,underlying diseases,course of disease,family history and past pulmonary diseases were compared,and the independent risk factors were summarized by unconditional logistic regression.Results The mutation rate of EGFR in adenocarcinoma was 57.59%,which was much higher than that of other pathological types(P<0.05).The mutation rate of EGFR in invasive lung adenocarcinoma was 66.9%,which was much higher than that in other invasive lung adenocarcinoma(P<0.05).(2)Smoking,lymph node metastasis,clinical stage(stageⅢ~Ⅳ),pleural invasion,female(P<0.05)were the single risk factors of EGFR mutation in the elderly,but not related to age,location of tumors,diameter of tumors,underlying diseases,course of disease,family history and past lung diseases(P>0.05).(3)Unconditional Logistic regression analysis showed that smoking,lymph node metastasis,clinical stage,pleural invasion and female were independent influencing factors of EGFR mutation in the elderly(P<0.05).Conclusion EGFR mutation is correlated with pathological data,sex,smoking,lymph node metastasis and clinical stage of lung cancer patients.There is a strong correlation between EGFR mutation and infiltration degree of lung adenocarcinoma.
作者
陈辉娥
姜训忠
聂鸿
李延东
周芳
潘琪
CHEN Huie;JIANG Xunzhong;NIE Hong(Shenzhen Integrated Traditional Chinese and Western Medicine Hospital,Shenzhen,518104)
出处
《实用癌症杂志》
2020年第11期1810-1813,共4页
The Practical Journal of Cancer
基金
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(编号:Z2016486)。
关键词
肺癌组织
表皮生长因子受体突变
影响因素
肿瘤病理学特征
Lung cancer tissue
Epidermal growth factor receptor mutation
Influencing factors
Tumor pathological characteristics
