摘要
[目的]研究牦牛胎盘粉对亚急性衰老小鼠心、肝、脾、肺、肾、骨骼肌中一氧化氮(NO)含量的影响。[方法]将健康小鼠随机分为正常对照组、模型组、阳性对照组、低海拔胎盘组、中海拔胎盘组和高海拔胎盘组,将除正常对照组外的其他5组用D-半乳糖,造亚急性衰老小鼠模型;然后对低、中和高海拔胎盘组的小鼠建模11 d后,每天灌胃牦牛胎盘粉,剂量为40 mg/kg。阳性对照组每天灌服维生素E 100 mg/kg,45 d后观察心、肝、脾、肺、肾组织中一氧化氮(NO)含量。[结果]高原牦牛胎盘粉可明显降低小鼠心、肝、脾、肺、肾组织中一氧化氮(NO)含量(P<0.01)。[结论]高原牦牛胎盘粉有很好的抗衰老作用。
[Objective] The purpose was to study the effect of yak placenta powder on NO content in heart, liver, spleen, lung and kidney, skeleton muscle of subacute aging model mice. [Method] The healthy mice were randomly divided into normal control group, model group, positive control group, low-elevation placenta group, middle-elevation placenta group and high-elevation placenta group. Five groups except for normal control group were used to construct subaeute aging mice model by D-galactose. 11 days later, the mice of the low-elevation, middle-elevation and high-elevation yak placenta powder groups were gastricly lavaged with yak placenta powder with its dose being of 400 mg/kg, respectively, positive control group were gastricly lavaged with Vitamin E 100mg/kg. After 45 days, the content of NO in heart, liver, spleen, lung and kidney, skeleton muscle were determinated. [Result] The results showed that yak placenta powder obviously, decrease the content of NO in heart, liver, spleen, lung and kidney, skeleton muscle, indicating that the yak placenta powder has good anti-aging effect.
出处
《安徽农业科学》
CAS
北大核心
2009年第18期8523-8524,共2页
Journal of Anhui Agricultural Sciences
关键词
牦牛胎盘
小鼠
抗衰老
NO
Yak
Placenta powder
Mice
Anti-aging effect
NO
