摘要
目的:观察复方丹参注射液对急性水肿型胰腺炎患者外周血中性粒细胞凋亡及IL-6和TNF-α水平的影响,探讨复方丹参注射液治疗急性胰腺炎的机制。方法:采用复方丹参注射液治疗35例急性水肿型胰腺炎患者,取常规治疗组40例作为对比观察,并于治疗前后检测患者外周血中性粒细胞凋亡和细胞因子IL-6和TNF-α水平。结果:加入复方丹参注射液治疗的急性胰腺炎组总有效率为91.43%,并能促进患者外周血中性粒细胞凋亡,降低血液中细胞因子IL-6和TNF-α的水平。结论:复方丹参注射液结合西医治疗对急性胰腺炎有显著疗效,可能与复方丹参注射液能调节中性粒细胞凋亡和炎性细胞因子的产生,抑制炎症反应有关。
Objective To study the effects of Salvia Miltiorrhiza injection（SMI） on the apoptosis of polymorphonu- clear leukocyte（PMN） and the levels of inflammatory cytokines TNF- α and IL- 6 in patients with acute edematous pan- creatitis. Methods Thirty- five patients with acute edematous pancreatitis were treated with SMI, and dO acute ede- matous pancreatitis patients remedied routinely were taken as contrasts. The apoptosis of PMN was detected with flow cy- tometry and the levels of cytokines IL - 6 and TNF --α were tested before and after treatment. Results The total utility rate （91.43%） of SMI to acute edematous pancreatitis was significantly higher than that of the control group （72. 50% ）. After the treatment, the apoptosis of PMNs was promoted in the acute edematous pancreatitis patient treated with SMI compared with the patients remedied routinely, and the levels of IL - 6 and TNF-α in the group treated with SMI were lower than those of control. Conclusion There was a significant therapeutic effect of SMI on patients with acute edematous pancreatitis. The therapeutic mechanism of SMI to acute pancreatitis might be the regulation of the apoptosis of PMN by this herbal medicine, thus controlling the production of inflammatory cytokines, so as to inhibit inflammatory reactions.
出处
《中国中西医结合外科杂志》
CAS
2009年第3期214-217,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
基金
广东省湛江市科技攻关计划项目(2005021
2008C01020)
