摘要
目的:探讨中风急性期中医辨证分型与中性粒细胞凋亡的关系。方法:采用流式细胞术检测237例中风急性期患者的血清中性粒细胞(PMN)凋亡率。结果:中风急性期患者在发病的72h内血清中PMN凋亡率显著低于健康对照组(P<0.01),且组内比较PMN凋亡率呈进行性降低趋势(P<0.05)。中脏腑患者PMN凋亡率明显低于中经络组(P<0.05);风痰火亢证、痰热腑实证、风痰瘀阻证、风火上扰证、痰湿蒙神证PMN凋亡率明显低于气虚血瘀证、阴虚风动证(P<0.05或0.01)。痰湿蒙神证、风火上扰证、风痰火亢证PMN凋亡率明显低于痰热腑实证、风痰瘀阻证、气虚血瘀证、阴虚风动证(P<0.05)。结论:中风病的致病因素、病情轻重和辨证分型与PMN凋亡率密切相关。
Objective ：To investigate the relationship between neutrophil apoptosis and traditional Chinese medical syndrome differentiation and typing in patients with acute stroke. Methods ： The apoptosis rate of serum neutrophil of 237 stroke patients and 30 normal controls were assayed by flow cytometry. Resu/ts ：The apoptosis rate of serum neutrophil of the patients were all significandy lower than those of the control group in 72 hours after stroke （ P 〈 0. 01 ）, and the apoptosis rate of neutrophil decreased gradually thereafter（P 〈 0. 05 ）. The apoptosis rate of neutrophil of the patients involving the Zang Fu organs syndromes were more lower than those involving the meridian and collateral syndrome （ P 〈 0. 05 ）, and the apoptosis rate of neutrophil of the patients with syndromes of wind phlegm fire excess,phlegm hot Fu substantial and wind phlegm blood stasis were significantly lower than those with Yin-deficincy wind-moving syndrome and of Qi deficiency and blood stasis syndrome （ P 〈 0. 01 or 0. 05 ）, and syndromes of phlegm-dampness Shen-closing,wind fire excess and wind phlegm fire excess were significantly lower than those of phlegm hot Fu substantial and wind phlegm blood stasis, Qi deficiency and blood stasis and Yin-deficincy wind-moving （P 〈 0. 05 or 0. 01 ）. Conclusion：The low apoptosis rate of serum neutrophil may be an important pathophysiological basis of acute apoplexly can become the objective criterion of different syndromes of acute apoplexly.
出处
《辽宁中医杂志》
CAS
北大核心
2009年第6期875-877,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
中风
急性
辨证分型
中性粒细胞凋亡
Acute apoplexly
Traditional Chinese medical syndrome differentiation and typing
Neutrophil apoptosis
