摘要
目的观察妊娠期糖尿病干预性治疗对胰岛素抵抗及胰岛β细胞功能的影响。方法选择妊娠期糖尿病(GDM)孕妇46例为GDM组,正常孕妇42例为对照组。通过饮食控制、合理运动和胰岛素治疗对GDM组进行干预性治疗,观察治疗前后胰岛素抵抗指数(IR)及胰岛素敏感指数(IS)的变化。结果治疗前GDM组与对照组比较,IR、IS差异有统计学意义(P<0.05)。控制血糖后,GDM组IR降低,IS升高,与治疗前比较差异有统计学意义(P<0.05)。结论胰岛素抵抗及胰岛分泌功能下降是GDM的发病原因之一,早期控制血糖可避免造成孕妇胰岛β细胞的永久损伤,减少孕妇产后发生2型糖尿病的机会,从而改善GDM孕妇及其胎儿的预后。
Objective To observe the effect of management of gestational diabetes mellitus on insulin resistance and pancreatic β cell function. Methods 46 cases pregnant women with gestational diabetes mellitus were selected as GDM group and 42 cases normal pregnancy women as control group. Such methods as alimentary control, reasonable exercise and insulin treatment were used in GDM group and IR and IS were observed before and after treatment. Results Before treatment,there were significantly different in IR and IS between the GDM group and the control group （P〈0.05）. After the blood glucose turned to normal level,IR was significantly decreased and IS was significantly increased in the GDM group（P〈 0.05）. Conclusions Insulin resistance and decreased insulin secretion function play an important role in the pathogenesis of GDM. Early controlling blood glucose level can avoid permanent damage of pancreatic β cell and reduce the risk of type 2 diabetes mellitus so as to improve the prognosis of GDM pregnant women and their fetus.
出处
《中国热带医学》
CAS
2009年第7期1267-1268,共2页
China Tropical Medicine
关键词
妊娠糖尿病
胰岛素抵抗
胰岛Β细胞功能
Gestational diabetes mellitus
Insulin resistance
Pancreatic β cell function
